This study was aimed to investigate the nephroprotective effect of capparis decidua aerial parts methanolic extract against gentamicin induced nephrotoxicity in wistar albino rats. In vitro antioxidant studies were carried out with dpph, hrsa, no, frap and lpo assays. Leaves of the ficus carica were collected from jamia hamdard hamdard university campus, new delhi, india and authenticated by. The experimental work described within this thesis was transported. In this study, it was observed that serum levels of. A large number of plants and formulations have been claimed to show hepatoprotective activities.
A number of studies have shown that the plant extracts having antioxidant activity protect against ccl4 hepatotoxicity by inhibiting lipid. Medicinal plants possessed hepatoprotective activity through many mechanisms, included antioxidant properties of medicinal plants, enhancement of antioxidant defense superoxid dismutase, catalase and glutathione peroxidase activity 12, reduced peroxidation34, reversed hepatic fibrosis via enhancement of the expression of matrix. These medicinal plants along with natural therapeutic value against various diseases, provide highquality food and raw materials. Hepatoprotective and antioxidant activity of ipomoea staphylina linn ramachandran jeyadevi1, devanesan arul ananth2 and thilagar sivasudha1 abstract background. Antioxidant and hepatoprotective effects of croton. Pdf the methanol extracts of plant materials of some plants like casuarina equisetifolia, cajanus cajan, glycosmis pentaphylla, bixa orellana. In this study, online databases including web of science, pubmed, scopus, and science direct were searched for papers. Natural antioxidant products are increasingly being used to treat various pathological liver conditions considering the role of oxidative stress in their pathogenesis. Group one was kept on normal diet and served as control, the second. Liver disease is one of the outrageous diseases all over the world.
Tea is a popular beverage and shows very strong in vitro antioxidant activity. D763600004 vinayaka missions university salem tamilnadu, india,he. Pdf medicinal plants with hepatoprotective activity in. The in vivo antioxidant and hepatoprotective actions of. The rats were divided into four groups, each group consisting of six animals. Medicinal plants possessed hepatoprotective activity. Recently, antimicrobial activity of aqueous extract of ipomoea reniformis has been reported 11. Institute of pharmacy 1, niet, greater noida 206, uttar pradesh, india. The plant have demonstrated significant pharmacological activities like antioxidant, anticarcinogenic, antiosteporotic and hepatoprotective. This article needs attention from an expert in medicine.
Pj p of the ethanolic extract of leaves prepared in methanol. Hepatoprotective and antioxidant activity of hydroalcoholic. However, the relationship among in vitro and in vivo antioxidant activities in teas is seldom reported. About 600 commercial herbal formulations with hepatoprotective activity are being sold all over the world. Thus, the present study was carried out to identify the hepatoprotective activity of plant parts leaf, bark, collar, flower and hypocotyls of c. The levels of hepatic marker enzymes, alanine aminotransferase alt, aspartate aminotransferase ast. Recent progress in the study of such plants has resulted in the isolation of about 170 different phytoconstituents from plants belonging to about 55 families, which exhibit hepatoprotective activity 79. Hence our study is focused on the study of efficacy and hepatoprotective activity of mimosa pudica on experimentally induced hepatotoxic rats.
According to the literature 10 anethum graveolens 9 l. Hepatoprotective activity of melia azedarach leaf extract against. Male albino rats weighing between 150 and 175 g were used as animal models. The identification of these molecules contained in a biomass complex requires careful selection and execution of appropriate bioassays during the various stages of the research process. Pdf hepatoprotective activity of some plants extract against. It is a nontoxic hepatoprotective substance from the.
The action of these plants is largely attributed to their phytoconstituents such as flavonoids, antioxidant, and. Evaluation of the hepatoprotective activity of fagonia. Liver injury induced by toxins is more common nowadays. Moringa oleifera lam moringaceae, commonly known as drumstick, is used in indian folk medicine for the treatment of various illness. The methanolic extracts, comparable to silymarin as a conventional drug, exhibited a higher hepatoprotective activity 25.
Dec 17, 2019 hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in rats. This present work investigated the hepatoprotective and antioxidant potential of aqueous extract of ipomoea staphylina leaves on wistar rats against ccl4induced liver injury. Around 160 active constituents from 101 plants are claimed to have post liver protecting activity. Mahmud, et al hepatoprotective activity of leaves of p. The indexed articles were found by searching through pubmed, medigraphic, imbiomed, scifinder and sciencedirect, using the following terms. There are a number of medicinal combinations in the iranian traditional medicine which are commonly used as tonic for liver. Hence, these plants are considered to be rich sources of steroids, triterpenoids, saponins, flavonoids, alkaloids, and tannins. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats find, read and cite all the. Antioxidant activity of rosemary rosmarinus officinalis. Twelve healthy albino rats were taken for the study. Various plants and polyherbal formulations have hepatoprotective activity.
In vitro hepatoprotective activity of the extract was evaluated at 20, 40, 60, 80 and 100 microgml concentration against ccl4 1% induced toxicity in freshly isolated rat hepatocytes. We have evaluated the hepatoprotective effect of an ethanolic extract of m. Medicinal plants with hepatoprotective activity contain a large number of bioactive molecules. Whereas most of the anti hepatoprotective activities of plants have been investigated utilizing chemical models, this is the first report to study the hepatoprotective effect of ethanol extracts of m. Twenty rats were divided into 4 groups of 5 rats each as follows, normal control. In general, the hepatoprotective activity of plants can be considered as an expression of the functional improvement of hepatocytes that results from accelerated cellular regeneration, 20, 25. Hepatoprotective activity of ceriops decandra griff.
Wikiproject medicine may be able to help recruit an expert. Hepatoprotective effects of medicinal plants against drug models of hepatotoxicity remain poorly understood. The hepatoprotective activity is probably due to the presence of flavonoids, phenolic compounds, polyphenols etc in all few herbal plants. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar. The results of this study indicate that extracts of leaves and plants extracts of some medicinal plant have good potentials for use in hepatic disease. Hepatoprotective activity of ethanol extract of conyza b.
Hepatoprotective activity of two plants belonging to the apiaceae and the euphorbiaceae family. However, a scientific evaluation has not been performed. Plants of the same genus such as ipomoea hederacea 9andipomoea obscura 10 have been reported for their hepatoprotective activity. Around 170 phytoconstituents isolated from 110 plants belonging to 55 families have been reported to possess hepatoprotective activity. Review on some medicinal plants with hepatoprotective. In india, numerous medicinal plants are used for the treatment of liver disorders.
There are many plants and traditional formulations available to treat the liver diseases 5, 6. Investigation of medicinal plants for hepatoprotective activity thesis submitted to partial fulfillment for the award of degree of doctor of philosophy in p harmacy submitted by p. The plant can be identified authenticated by department of botany, research office botanist. Further study is needed to find out the curative effect and to isolate the active principle and to explore out the exact hepatoprotective mechanism of this plant extract. Hepatoprotective activities of two ethiopian medicinal plants. Hepatoprotective and antioxidant activity of ethanol extract. For this purpose, seventeen plants were selected for which recent articles were available that a studied in vitro and in vivo hepatoprotective activities of herbal prod. Hepatoprotective activity of the ethanolic extract of ficus caricalinn. It is estimated that around 70,000 plants species from lichens to towering trees has been used for medicinal purpose. Hepatoprotective and antioxidant activity of ipomoea. Possible mechanism for hepatoprotective activity may be due to free radical scavenging potential in extracts. Nephroprotective activity of capparis decidua aerial parts.
In early study we have shown that peptides obtained from 7 plantain plantago major l. Apr 26, 2019 medicinal and aromatic plants have the potential to treat various disorders both human and animals. This present work investigated the hepatoprotective and antioxidant potential of. Deccan school of pharmacy 1, hyderabad, andhra pradesh, india. Allium sativum the antihepatic toxicity of garlic was investigated experimentally in rats, crcl3 alone increased serum levels of ast and alt. The previous investigations 26 has revealed that hepatoprotective effects are linked with natural antioxidants. Medicinal plants possessed hepatoprotective ac tivity ali e alsnafi 1, hameed n mousa 2 and w ajdi j majid 3 1 dept. Hepatoprotective activities of triphala and its constituents. Hepatoprotective activity of some medicinal plants in sudan. Hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in rats.
Hepatoprotective activity of some medicinal plants in sudan hindawi. A study on hepatoprotective activity of mimosa pudica in. Look at some indian medicinal plants for hepatoprotective activity g. Hepatoprotective activity of some medicinal plants in sudan ncbi. More studies to find out the scientific basis of herbal treatment. Liver cell injury caused by various toxic chemicals certain antibiotic, chemotherapeutic agents, carbon. Sterculiaceae family were studied for hepatoprotective activity against albino rats with liver damage induced by paracetamol. In vitro assessment of hepatoprotective agents against. In vitro bioassays are important in the evaluation of plants with possible hepatoprotective effects. Reports on the hepatoprotective activity of the following species have been published. Literature was retrieved using the key words and phrases hepatitis c, hepatoprotective activity, mechanism of action, medicinal plants, herbal, and treatment. Ning w, peibo li, yonggang w, wei p, zhong w, suiyi t, shaoling l, xiao s and weiwei su. Review of plants with hepatoprotective activity evaluated.
Herbal plants or botanical medicines have been used traditionally by herbalist worldwide for the prevention and treatment of liver disease. Hepatotoxicity and the role of some herbal hepatoprotective plants. Medicinal plants play an important role in the lives of rural people particularly in remote parts of developing countries with few health facilities. Traditionally, medicinal plants play a major role in the treatment of diseases. In india, quite eighty seven plants square measure used in 33 patented propitiatory multi. Natural medications are more efficient and safer option approach for hepatotoxicity. Antioxidant and hepatoprotective activities of ethanolic. Hepg2 cells showed significant dose dependent increase in percentage viability at the doses 20, 40, 60, 80 and 100 gml of cpre compared to ccl 4 exposed hepg2 cells. Medicinal and aromatic plants have the potential to treat various disorders both human and animals. Carbon tetrachloride, hepatoprotection, paracetamol, psidium guajava, thioacetamide liver diseases, such as jaundice, cirrhosis and fatty liver are very common worldwide. About 100 relevant articles were extracted after a narrow search for a combination of the keywords and subsequent analysis per the inclusion criteria.
Is a small spiny under shrub mostly found in dry calcareous rocks, belongs to family zygophyllaceae 11, it is locally known as shokat algemal, umm shawaika and al agoul, and found in the west, northern and central sudan 12. Hepatoprotective effect of hypericum japonicum extract and its fractions. Oral administration of an aqueous extract of andrographis 10, 20 and 30 mg per mouse caused a significant elevation of catalase, sod and glutathionestransferase activities in lymphoma. The 2nd criteria were used for selecting those plants that are discussed in detail shown in figure 3. In this study, in vivo antioxidant and hepatoprotective activities of 32 selected chinese teas were evaluated on a mouse model with acute alcoholinduced liver injury. The hepatoprotective activity of these plants is based on lowering liver biomarkers as well as suppressing of degenerative changes in hepatocytes produced by. The 2nd criteria were used for selecting those plants that are discussed in detail shown in. Hepatoprotective activity of some indigenous plants sharma bhawna1, sharma upendra kumar2 institute of pharmacy b. Three studies cited above attest to significant in vivo and in vitro antioxidant activity for the herb, 87,93,100 as do some of the hepatoprotection studies. Scrophulariaceae used in ethiopian traditional medical practices for the treatment of liver diseases.
Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. Pdf hepatoprotective activity of some plants extract. Sitha institute of pharmaceutical sciences 2, hyderabad, andhra pradesh. In folklore medicine, ceriops decandra is used to treat hepatitis. In vitro and in vivo hepatoprotective activity of cissampelos. Hepatic useful new compounds for the development of effe. Plants contain a variety of chemical constituents like phenols, carotenoids, glycosides, flavonoids, organic acids, lipids and alkaloids which showed hepatoprotective activity.
In vitro free radical scavenging activity of aqueous extract of ipomoea staphylina ais was estimated using abts 2, 2. The hepatoprotective effect of extracts was further confirmed by histopathological studies of liver, which shows normal architecture of liver cell than compared with hepatotoxicant group. Hepatoprotective activity of some indigenous plants. Therefore, slm that has been employed as a protective treatment of liver disease by its antioxidant properties deriving from the phenolic nature of.
Medicinal plants possessed hepatoprotective activity 27 body weight in rats protect liver enzymes, oxidation status mda and gsh, fucosidase tumor marker and risk lipid ratio1112. Herbal remedies are focused in the pharmaceutical industry to evolve a safe route for. Hepatoprotective effect of citral on acetaminopheninduced. The prevention of liver damage induced by ccl4 has widely been used as a marker of hepatoprotective activity of drugs in general 14. Nature is the source of wide range of plants with medicinal value. Hepatoprotective activity of two plants belonging to the. The hepatoprotective activity of conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. Employed by an writing company phd thesis on hepatoprotective activity find bargain crafting a resume. Polyherbal formulations reputed to have hepatoprotective activity that are available on the indian market comprise about 100 indian medicinal plants handa et al. These plants are used in traditional system medicine in the treatment of jaundice.
The present study evaluated the in vivo hepatoprotective activity of two medicinal plants, namely, justicia schimperiana hochst. Hepatoprotective activity of medicinal plants thesis proposal. Pdf hepatoprotective activity of methanol extract of some. The antioxidant and hepatoprotective activity of of i. The petroleum ether extract at 50 mgkg was having best activity as it decreased the mean level of bilirubin from 2. Recent experience has shown that plant drugs are nontoxic, safe and even free from side effects 4. Comparative hepatoprotective activities of selected indian. The action of these plants is largely attributed to their phytoconstituents such as flavonoids, antioxidant, and antiinflammatory effects.
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